JG, maybe a good place to look for background is the paper of Chang, Weinberger, and Yu: Taming 3-manifolds using scalar curvature. They prove that if your M (contractible) is complete and if scal is uniformly positive, then it is homeomorphic to $mathbb{R}^3$...this is weaker than assuming $sec>0$ and using something like the Soul Theorem.
Also, check out Ross Geoghegan's "Topological methods in group theory."
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