"Special case of a general theorem of Lagrange" doesn't sound well to me: Wikipedia writes that "Lagrange (1773) treated determinants of the second and third order. Lagrange was the first to apply determinants to questions of elimination theory; he proved many special cases of general identities.", so I think your original question is already more general than anything Lagrange has done.
Here are two simple generalizations of your original question:
(1) If
$left(begin{array}{cccc}A_{1,1}&A_{1,2}&dots &A_{1,n} \ A_{2,1}&A_{2,2}&dots &A_{2,n}\ vdots &vdots &ddots &vdots \ A_{n,1}&A_{n,2}&dots &A_{n,n}end{array}right)$
is a block matrix with
$A_{i,j}=0$ for every $i < j$, and
$A_{i,i}$ being a square matrix for every $i$,
then its determinant is $det A_{1,1}cdot det A_{2,2}cdot dots cdot det A_{n,n}$.
The easiest proof (imho) uses the Leibniz formula for determinants, which reduces it to the following combinatorial fact: If a finite set $S$ is the union of some pairwise disjoint sets $S_1$, $S_2$, ..., $S_n$, and $pi$ is a permutation of the set $S$, then either $pileft(S_iright)=S_i$ for every $i$, or there exist $i < j$ such that $pi$ maps at least one element of $S_j$ into $S_i$. This is an exercise in induction.
(2) Another generalization: If $left(U_iright)_{iinmathbb Z}$ is an exact chain complex of finite-dimensional vector spaces, bounded from below and from above (i. e., the vector space $U_i$ is zero for all sufficiently large $i$ and for all sufficiently small $i$), and $left(f_iright)_{iinmathbb Z}$ is a chain homomorphism from $left(U_iright)_{iinmathbb Z}$ to $left(U_iright)_{iinmathbb Z}$, then
$prodlimits_{iinmathbb{Z}; itext{ is even}}det f_i=prodlimits_{iinmathbb{Z}; itext{ is odd}}det f_i$.
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